Article
Redox proteomics analyses of the influence of co-expression of wild-type or mutated LRRK2 and Tau on C. elegans protein expression and oxidative modification: relevance to Parkinson disease.
Antioxidants & redox signaling - 1 Dec 2012
Di Domenico Fabio, Sultana Rukhsana, Ferree Andrew, Smith Katelyn, Barone Eugenio, Perluigi Marzia, Coccia Raffaella, Pierce William, Cai Jian, Mancuso Cesare, Squillace Rachel, Wiengele Manfred, Dalle-Donne Isabella, Wolozin Benjamin, Butterfield D Allan
Abstract excerpt
AIMS: The human LRRK2 gene has been identified as the most common causative gene of autosomal-dominantly inherited and idiopathic Parkinson disease (PD). The G2019S substitution is the most common mutation in LRRK2. The R1441C mutation also occurs in cases of familial PD, but is not as prevalent. Some cases of LRRK2-based PD exhibit Tau pathology, which suggests that alterations on LRRK2 activity affect the...
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