Article

A Peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms

2022-11-15

Abstract excerpt

<h4>Summary</h4> Peroxiredoxins (Prdx) utilize reversibly oxidized cysteine residues to reduce peroxides but also to promote H 2 O 2 signal transduction, including H 2 O 2 -induced activation of P38 MAPK. Prdx form H 2 O 2 -induced disulfide complexes with many proteins, including multiple kinases involved in P38 MAPK signaling. Here we show that a genetically-encoded fusion between Prdx and the P38 MAPK is...

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Literature Corpus work: f4835705-6289-5350-bc0a-3faaf6566285
DOI: 10.1101/2022.11.15.513554

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A Peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanismsDOI 10.1101/2022.11.15.513554Read

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