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Spatial MALDI-MSI Reveals a Coordinated Vicious Cycle of Oxidative Membrane Damage and Ceramide-Driven Sphingolipid Dysregulation in the Chronically Neuroinflamed Brain

2026-07-20

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Chronic neuroinflammation is a major driver of cognitive decline, vascular cognitive impairment, and Alzheimer’s disease. However, the spatial lipidomic alterations underlying neuroinflammatory brain injury remain poorly defined. Oxidative stress and sphingolipid dysregulation have been implicated, but their regional distribution and interplay in the brain are not well chara...

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Literature Corpus work
24fd6611-2201-52d7-a6b4-47b7b768e2ef
DOI
10.64898/2026.07.14.738110
Open publication

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