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Article

Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics.

PloS one - 1 Jan 2011

Han Xianlin, Rozen Steve, Boyle Stephen H, Hellegers Caroline, Cheng Hua, Burke James R, Welsh-Bohmer Kathleen A, Doraiswamy P Murali, Kaddurah-Daouk Rima

Abstract excerpt

BACKGROUND: The development of plasma biomarkers could facilitate early detection, risk assessment and therapeutic monitoring in Alzheimer's disease (AD). Alterations in ceramides and sphingomyelins have been postulated to play a role in amyloidogensis and inflammatory stress related neuronal apoptosis; however few studies have conducted a comprehensive analysis of the sphingolipidome in AD plasma using...

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PMID: 21779331
DOI: 10.1371/journal.pone.0021643
PMCID: PMC3136924

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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