Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low plasma ApoE levels are associated with smaller hippocampal size in the Alzheimer's disease neuroimaging initiative cohort.

Dementia and geriatric cognitive disorders - 1 Jan 2015

Teng Edmond, Chow Nicole, Hwang Kristy S, Thompson Paul M, Gylys Karen H, Cole Gregory M, Jack Clifford R, Shaw Leslie M, Trojanowski John Q, Soares Holly D, Weiner Michael W, Apostolova Liana G

Abstract excerpt

Apolipoprotein E (APOE) genotype is the strongest known genetic risk factor for sporadic Alzheimer's disease (AD), but the utility of plasma ApoE levels for assessing the severity of underlying neurodegenerative changes remains uncertain. Here, we examined cross-sectional associations between plasma ApoE levels and volumetric magnetic resonance imaging indices of the hippocampus from 541 participants [57 with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Apolipoprotein E4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognitive Dysfunction

Share to Hippocampus

Share to Longitudinal Studies

Share to Neuroimaging

Share to Neuropsychological Tests

Share to Organ Size

Source

Open in PubMed Open full text

Identifiers

PMID: 25547651
DOI: 10.1159/000368982
PMCID: PMC4323932

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low plasma ApoE levels are associated with smaller hippocampal size in the Alzheimer's disease neuroimaging initiative cohort.PMID 25547651Read ↗

Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease.Semantic proximity Read ↗

Hippocampal volumes in UK Biobank are associated with APOE only in older adultsSemantic proximity Read ↗

Hippocampal volumes in UK Biobank are associated with APOE only in older adultsSemantic proximity Read ↗

APOE genotype and neuroimaging markers of Alzheimer's disease: systematic review and meta-analysis.Semantic proximity Read ↗

Effect of APOE Genotype on Amyloid Deposition, Brain Volume, and Memory in Cognitively Normal Older Individuals.Semantic proximity Read ↗

APOE ε4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory.Semantic proximity Read ↗

APOE in the normal brainSemantic proximity Read ↗

The selective vulnerability of the left fimbria in cognitively normal APOE ε4 carriers: a localized structural correlate of high genetic risk for Alzheimer's disease.Semantic proximity Read ↗

APOE4 is associated with greater atrophy of the hippocampal formation in Alzheimer's diseaseSemantic proximity Read ↗

Mapping the effect of the apolipoprotein E genotype on 4-year atrophy rates in an Alzheimer disease-related brain network.Semantic proximity Read ↗

Differences in Alzheimer's Disease-Related Pathology Profiles Across Apolipoprotein Groups.Semantic proximity Read ↗

The impact of APOE ε4 in Alzheimer’s disease: a meta-analysis of voxel-based morphometry studiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.