Gene polymorphism -418 G/C of tissue inhibitor of metalloproteinases 2 is associated with abdominal aortic aneurysm.

doi:10.1016/j.jvs.2013.12.045

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Article

Gene polymorphism -418 G/C of tissue inhibitor of metalloproteinases 2 is associated with abdominal aortic aneurysm.

Journal of vascular surgery - 1 May 2015

Mikołajczyk-Stecyna Joanna, Korcz Aleksandra, Gabriel Marcin, Pawlaczyk Katarzyna, Oszkinis Grzegorz, Słomski Ryszard

Abstract excerpt

OBJECTIVE: The pathogenesis of abdominal aortic aneurysm (AAA) is connected with abnormal extracellular matrix remodeling, with the assistance of extracellular matrix metalloproteinases and tissue inhibitors of metalloproteinases (TIMPs). A decrease in tissue inhibitor of metalloproteinases 2 (TIMP2) gene expression was detected in AAA patients. Recently, a -418 G/C (rs8179090) polymorphism of the TIMP2 gene...

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PMID: 24534323
DOI: 10.1016/j.jvs.2013.12.045

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TIMP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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