Article
The hOGG1 Ser326Cys gene polymorphism and the risk of coronary ectasia in the Chinese population.
International journal of molecular sciences - 22 Jan 2014
Hsu Po-Chao, Wang Chiao-Ling, Su Ho-Ming, Juo Suh-Hang, Lin Tsung-Hsien, Voon Wen-Chol, Shin Shyi-Jang, Lai Wen-Ter, Sheu Sheng-Hsiung
Abstract excerpt
Oxidative stress (OS) is related to vascular inflammation possibly, contributing to the development of coronary ectasia (CE). Base excision repair (BER) and nucleotide excision repair are the main DNA repair pathways that can help to remove 8-hydroxydeoxyguanine (8-OHdG), a marker of OS. Human 8-oxoguanine DNA glycosylase 1 (hOGG1) is a key enzyme of the BER pathway and catalyzes the removal of 8-OHdG. The aim of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
