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Article

Dual role of SIRT1 in UVB-induced skin tumorigenesis.

Oncogene - 15 Jan 2015

Ming M, Soltani K, Shea C R, Li X, He Y Y

Abstract excerpt

The protein deacetylase SIRT1 regulates various pathways in metabolism, aging and cancer. However, the role of SIRT1 in skin cancer remains unclear. Here, using mice with targeted deletions of SIRT1 in their epidermis in both resistant B6 and sensitive SKH1 hairless backgrounds, we show that the role of SIRT1 in skin cancer development induced by ultraviolet B (UVB) radiation is dependent on its gene dose....

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Topics

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Share to Carcinogenesis
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Share to Neoplasms, Radiation-Induced

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24441046
DOI: 10.1038/onc.2013.583
PMCID: PMC4104262

Genes

SIRT1
XPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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