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Article

SIRT1 inhibition restores apoptotic sensitivity in p53-mutated human keratinocytes.

Toxicology and applied pharmacology - 15 Jun 2014

Herbert Katharine J, Cook Anthony L, Snow Elizabeth T

Abstract excerpt

Mutations to the p53 gene are common in UV-exposed keratinocytes and contribute to apoptotic resistance in skin cancer. P53-dependent activity is modulated, in part, by a complex, self-limiting feedback loop imposed by miR-34a-mediated regulation of the lysine deacetylase, SIRT1. Expression of nu...

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Source

Identifiers

PMID: 24726431
DOI: 10.1016/j.taap.2014.04.001

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24726431-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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