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Article

SIRT6 Promotes COX-2 Expression and Acts as an Oncogene in Skin Cancer

14 Oct 2014

Abstract excerpt

SIRT6 is a SIR2 family member that regulates multiple molecular pathways involved in metabolism, genomic stability, and aging. It has been proposed previously that SIRT6 is a tumor suppressor in cancer. Here, we challenge this concept by presenting evidence that skin-specific deletion of SIRT6 in the mouse inhibits skin tumorigenesis. SIRT6 promoted expression of COX-2 by repressing AMPK signaling, thereby...

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PMID: 25320180
DOI: 10.1158/0008-5472.can-14-1308

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