Mammalian <scp>SIRT</scp>2 inhibits keratin 19 expression and is a tumor suppressor in skin

Abstract excerpt

SIRT2 is a member of the mammalian sirtuin family (SIRT1-7). As compared with other sirtuins, SIRT2 is found primarily in the cytoplasm. It regulates multiple physiological processes. However, the precise role of SIRT2 in skin cancer remains unclear. Here, we show that SIRT2 is downregulated in human skin cancer as compared with normal skin. SIRT2 deletion increases tumor growth in mice. SIRT2 knockdown...

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