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Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C

13 Dec 2010

Abstract excerpt

Disruption of the nucleotide excision repair (NER) pathway by mutations can cause xeroderma pigmentosum, a syndrome predisposing affected individuals to development of skin cancer. The xeroderma pigmentosum C (XPC) protein is essential for initiating global genome NER by recognizing the DNA lesion and recruiting downstream factors. Here we show that inhibition of the deacetylase and longevity factor SIRT1 impairs...

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PMID: 21149730
DOI: 10.1073/pnas.1010377108

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