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Mitochondrial Sirtuins in Skin and Skin Cancers

3 Mar 2020

Abstract excerpt

Mammalian sirtuins (SIRTs 1-7) are a family of NAD+-dependent deacetylases with distinct subcellular localization and biological functions that regulate various important cellular processes. Among these, SIRTs -3, -4 and -5 are located in the mitochondria and have been implicated in caloric restriction, oxidative stress, aging and various human diseases. Emerging evidence has found dysregulation of mitochondrial...

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PMID: 32124989
DOI: 10.1111/php.13254

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