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Article

SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol.

Oncogene - 13 Aug 2009

Boily G, He X H, Pearce B, Jardine K, McBurney M W

Abstract excerpt

The function of the class III histone deacetylase, Sir2, in promoting lifespan extension is well established in small model organisms. By analogy, SirT1, the mammalian orthologue of Sir2, is a candidate gene to slow down aging and forestall the onset of age-associated diseases. We have used SirT1...

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PMID: 19503100
DOI: 10.1038/onc.2009.147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19503100-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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