A Novel<i>ADIPOQ</i>Mutation (p.M40K) Impairs Assembly of High-Molecular-Weight Adiponectin and Is Associated With Early-Onset Obesity and Metabolic Syndrome

Abstract excerpt

CONTEXT: The phenotypic effects of ADIPOQ mutations early in life, prior to type 2 diabetes onset, have not been studied. AIM: The objective of the study was to characterize the impact of a novel ADIPOQ mutation in vitro and in vivo. DESIGN: The design of the study was ADIPOQ screening, adiponectin oligomerization, and cardiometabolic phenotype assessment. SUBJECTS: Fourteen hypoadiponectinemic (<3 μg/mL) and 686...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adipokines, Inflammation, and Metabolic Diseases
• Share to Adipose Tissue and Metabolism
• Share to Regulation of Appetite and Obesity