Article
Hypoadiponectinemia is associated with progression toward type 2 diabetes and genetic variation in the ADIPOQ gene promoter.
Diabetes care - 1 Jul 2006
Schwarz Peter E H, Towers Gordon W, Fischer Sabine, Govindarajalu Suresh, Schulze Jan, Bornstein Stephan R, Hanefeld Markolf, Vasseur Francis
Abstract excerpt
OBJECTIVE: Adiponectin encoded by the ADIPOQ gene modulates insulin sensitivity and glucose homeostasis. The aim of the current study was to investigate whether ADIPOQ gene variants in the promoter region predict adiponectin levels and type 2 diabetes progression. RESEARCH DESIGN AND METHODS: A total of 550 subjects with increased risk of type 2 diabetes were investigated; they underwent a 75-g oral glucose...
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