Article
Novel adiponectin variants identified in type 2 diabetic patients reveal multimerization and secretion defects.
PloS one - 1 Jan 2011
Jungtrakoon Prapaporn, Plengvidhya Nattachet, Tangjittipokin Watip, Chimnaronk Sarin, Salaemae Wanisa, Chongjaroen Nalinee, Chanprasert Kanjana, Sujjitjoon Jatuporn, Srisawat Chatchawan, Yenchitsomanus Pa-Thai
Abstract excerpt
ADIPOQ, encoding adiponectin, is a candidate gene for type 2 diabetes (T2D) identified by genome-wide linkage analyses with supporting evidence showing the protein function in sensitizing insulin actions. In an endeavor to characterize candidate genes causing T2D in Thai patients, we identified 10 novel ADIPOQ variations, several of which were non-synonymous variations observed only in the patients. To examine...
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