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Article

Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci.

PLoS genetics - 1 Apr 2011

Paré Guillaume, Ridker Paul M, Rose Lynda, Barbalic Maja, Dupuis Josée, Dehghan Abbas, Bis Joshua C, Benjamin Emelia J, Shiffman Dov, Parker Alexander N, Chasman Daniel I

Abstract excerpt

Soluble ICAM-1 (sICAM-1) is an endothelium-derived inflammatory marker that has been associated with diverse conditions such as myocardial infarction, diabetes, stroke, and malaria. Despite evidence for a heritable component to sICAM-1 levels, few genetic loci have been identified so far. To comprehensively address this issue, we performed a genome-wide association analysis of sICAM-1 concentration in 22,435...

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Share to ABO Blood-Group System
Share to Adaptor Proteins, Signal Transducing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to I-kappa B Kinase

Share to Intercellular Adhesion Molecule-1

Share to Intracellular Signaling Peptides and Proteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 21533024
DOI: 10.1371/journal.pgen.1001374
PMCID: PMC3080865

Genes

PNPLA3
RELA
ABO
ICAM1
NFKBIB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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