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Article

A systematic analysis of gene-gene interaction in multiple sclerosis.

BMC medical genomics - 30 Apr 2022

Slim Lotfi, Chatelain Clément, Foucauld Hélène de, Azencott Chloé-Agathe

Abstract excerpt

BACKGROUND: For the most part, genome-wide association studies (GWAS) have only partially explained the heritability of complex diseases. One of their limitations is to assume independent contributions of individual variants to the phenotype. Many tools have therefore been developed to investigate the interactions between distant loci, or epistasis. Among them, the recently proposed EpiGWAS models the...

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Identifiers

PMID: 35501860
DOI: 10.1186/s12920-022-01247-3
PMCID: PMC9063218

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