Article
Pathway and network-based analysis of genome-wide association studies in multiple sclerosis.
Human molecular genetics - 1 Jun 2009
Baranzini Sergio E, Galwey Nicholas W, Wang Joanne, Khankhanian Pouya, Lindberg Raija, Pelletier Daniel, Wu Wen, Uitdehaag Bernard M J, Kappos Ludwig, Polman Chris H, Matthews Paul M, Hauser Stephen L, Gibson Rachel A, Oksenberg Jorge R, Barnes Michael R
Abstract excerpt
Genome-wide association studies (GWAS) testing several hundred thousand SNPs have been performed in multiple sclerosis (MS) and other complex diseases. Typically, the number of markers in which the evidence for association exceeds the genome-wide significance threshold is very small, and markers that do not exceed this threshold are generally neglected. Classical statistical analysis of these datasets in MS...
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