Article
Network-based multiple sclerosis pathway analysis with GWAS data from 15,000 cases and 30,000 controls.
American journal of human genetics - 6 Jun 2013
Abstract excerpt
Multiple sclerosis (MS) is an inflammatory CNS disease with a substantial genetic component, originally mapped to only the human leukocyte antigen (HLA) region. In the last 5 years, a total of seven genome-wide association studies and one meta-analysis successfully identified 57 non-HLA susceptibility loci. Here, we merged nominal statistical evidence of association and physical evidence of interaction to conduct...
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