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MicroRNA Let-7a and dicer are important in the activation and implantation of delayed implanting mouse embryos

12 Jan 2014

Abstract excerpt

STUDY QUESTION: Does Let-7a have a functional role in modulating dicer expression to activate dormant mouse blastocysts for implantation? SUMMARY ANSWER: Let-7a post-transcriptionally regulates dicer expression altering microRNA expression to affect the implantation competency of the activated blastocysts. WHAT IS KNOWN ALREADY: The Let-7a microRNA is up-regulated during blastocyst dormancy and its...

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PMID: 24419497
DOI: 10.1093/humrep/det462

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