Article
Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice.
The Journal of clinical investigation - 1 May 2008
Otsuka Motoyuki, Zheng Min, Hayashi Masaaki, Lee Jing-Dwan, Yoshino Osamu, Lin Shengcai, Han Jiahuai
Abstract excerpt
The microRNA (miRNA) processing enzyme Dicer1 is required for zygotic and embryonic development, but the early embryonic lethality of Dicer1 null alleles in mice has limited our ability to address the role of Dicer1 in normal mouse growth and development. To address this question, we used a mouse mutant with a hypomorphic Dicer1 allele (Dicer(d/d)) and found that Dicer1 deficiency resulted in female infertility....
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