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Genetic studies of Crohn's disease: past, present and future.

Best practice & research. Clinical gastroenterology - 1 Jun 2014

Liu Jimmy Z, Anderson Carl A

Abstract excerpt

The exact aetiology of Crohn's disease is unknown, though it is clear from early epidemiological studies that a combination of genetic and environmental risk factors contributes to an individual's disease susceptibility. Here, we review the history of gene-mapping studies of Crohn's disease, from the linkage-based studies that first implicated the NOD2 locus, through to modern-day genome-wide association studies...

Topics

Crohn Disease
Disease Susceptibility
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Genetic Variation
Genome-Wide Association Study
Genomics
Humans
Nod2 Signaling Adaptor Protein
Risk Factors

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Identifiers

PMID: 24913378
DOI: 10.1016/j.bpg.2014.04.009
PMCID: PMC4075408

Genes

NOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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