Article
IBD Genetic Risk Profile in Healthy First-Degree Relatives of Crohn's Disease Patients.
Journal of Crohn's & colitis - 1 Feb 2016
Kevans David, Silverberg Mark S, Borowski Krzysztof, Griffiths Anne, Xu Wei, Onay Venus, Paterson Andrew D, Knight Jo, Croitoru Ken
Abstract excerpt
BACKGROUND: Family history provides important information on risk of developing inflammatory bowel disease [IBD], and genetic profiling of first-degree relatives [FDR] of Crohn's disease [CD]- affected individuals might provide additional information. We aimed to delineate the genetic contribution to the increased IBD susceptibility observed in FDR. METHODS: N = 976 Caucasian, healthy, non-related FDR; n = 4997...
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