Dissecting Allele Architecture of Early Onset IBD Using High-Density Genotyping.

doi:10.1371/journal.pone.0128074

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Article

Dissecting Allele Architecture of Early Onset IBD Using High-Density Genotyping.

PloS one - 1 Jan 2015

Cutler David J, Zwick Michael E, Okou David T, Prahalad Sampath, Walters Thomas, Guthery Stephen L, Dubinsky Marla, Baldassano Robert, Crandall Wallace V, Rosh Joel, Markowitz James, Stephens Michael, Kellermayer Richard, Pfefferkorn Marian, Heyman Melvin B, LeLeiko Neal, Mack David, Moulton Dedrick, Kappelman Michael D, Kumar Archana, Prince Jarod, Bose Promita, Mondal Kajari, Ramachandran Dhanya, Bohnsack John F, Griffiths Anne M, Haberman Yael, Essers Jonah, Thompson Susan D, Aronow Bruce, Keljo David J, Hyams Jeffrey S, Denson Lee A, Kugathasan Subra

Abstract excerpt

BACKGROUND: The inflammatory bowel diseases (IBD) are common, complex disorders in which genetic and environmental factors are believed to interact leading to chronic inflammatory responses against the gut microbiota. Earlier genetic studies performed in mostly adult population of European descent identified 163 loci affecting IBD risk, but most have relatively modest effect sizes, and altogether explain only...

Topics

Adult
Age of Onset
Alleles
Base Sequence
Child
Colitis, Ulcerative
Crohn Disease
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Genotype

Humans

Male

Nod2 Signaling Adaptor Protein

Polymorphism, Single Nucleotide

Receptors, Interleukin

Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 26098103
DOI: 10.1371/journal.pone.0128074
PMCID: PMC4476779

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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