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Genetic Risk of Inflammatory Bowel Disease Is Associated With Disease Course Severity.

Gastroenterology - 1 Apr 2026

Vestergaard Marie Vibeke, Allin Kristine Højgaard, Nøhr Anne Krogh, Torresano Lominchar Jesus Vicente, Christensen Heidi Søgaard, Krarup Henrik, Nielsen Kaspar René, Jacobsen Henrik Albæk, Bybjerg-Grauholm Jonas, Bækvad-Hansen Marie, Brøndum Rasmus Froberg, Bøgsted Martin, Larsen Lone, Sazonovs Aleksejs, Jess Tine

Abstract excerpt

BACKGROUND & AIMS: Genetic susceptibility to inflammatory bowel disease (IBD) has been widely studied, whereas the genetic contribution to disease progression remains relatively underinvestigated. In a Danish nationwide cohort, we aimed to explore if genetic susceptibility to IBD associated with disease severity. METHODS: We estimated IBD polygenic scores (PGS) for 3732 patients with Crohn's disease (CD) and 4535...

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C-Reactive Protein
Colitis, Ulcerative
Crohn Disease
Denmark

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Risk Score

Hospitalization

Leukocyte L1 Antigen Complex

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PMID: 41665577
DOI: 10.1053/j.gastro.2025.09.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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