Article

Granulin Loss of Function in Human Mature Brain Organoids Implicates Astrocytes in TDP-43 Pathology

2022-10-25

Abstract excerpt

<h4>Summary</h4> Loss of function (LoF) of Tar-binding protein 43 (TDP-43) and mislocalization, together with TDP-43-positive and hyperphosphorylated inclusions, are found in postmortem tissue of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients, including those carrying LoF variants in the progranulin gene ( GRN ). Modelling TDP-43 pathology has been challenging in vivo and in vit...

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Literature Corpus work: 99d5a9e6-89bb-5dbd-8174-3eefb0e8f3a0
DOI: 10.1101/2022.10.24.513566

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