Article
Mutations in GFAP Alter Early Lineage Commitment of Organoids.
Glia - 1 Nov 2025
Dykstra Werner, Matusova Zuzana, Battaglia Rachel A, Abaffy Pavel, Goya-Iglesias Nuria, Pérez-Sala Dolores, Ahlenius Henrik, Kubista Mikael, Pasterkamp R Jeroen, Li Li, Chao Jianfei, Shi Yanhong, Valihrach Lukas, Pekny Milos, Hol Elly M
Abstract excerpt
Glial fibrillary acidic protein (GFAP) is a type-3 intermediate filament protein mainly expressed in astrocytes in the central nervous system. Mutations in GFAP cause Alexander disease (AxD), a rare and fatal neurological disorder. How exactly mutant GFAP eventually leads to white and gray matter deterioration in AxD remains unknown. GFAP is known to be expressed also in neural precursor cells in the developing...
Topics
- Glial Fibrillary Acidic Protein
- Organoids
- Mutation
- Induced Pluripotent Stem Cells
- Alexander Disease
- Humans
- Cell Lineage
- Cell Differentiation
- Cells, Cultured