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Article

Electrostatic charge at position 552 affects the activation and permeation of FMRFamide-gated Na+ channels.

The journal of physiological sciences : JPS - 1 Mar 2014

Kodani Yu, Furukawa Yasuo

Abstract excerpt

The FMRFamide-gated Na(+) channel (FaNaC) is a unique peptide-gated sodium channel and a member of the epithelial sodium channel/degenerin family. Previous studies have shown that an aspartate residue (Asp(552)) in the second transmembrane domain is involved in activation of the FaNaC. To examine the significance of a negative charge at position 552, we used a cysteine-modification method. Macroscopic currents of...

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Identifiers

PMID: 24415456
DOI: 10.1007/s12576-013-0303-6
PMCID: PMC10717150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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