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Article

On the interaction between amiloride and its putative alpha-subunit epithelial Na+ channel binding site.

The Journal of biological chemistry - 15 Jul 2005

Kashlan Ossama B, Sheng Shaohu, Kleyman Thomas R

Abstract excerpt

The epithelial Na+ channel (ENaC) belongs to the structurally conserved ENaC/Degenerin superfamily. These channels are blocked by amiloride and its analogues. Several amino acid residues have been implicated in amiloride binding. Primary among these are alphaSer-583, betaGly-525, and gammaGly-542...

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Identifiers

PMID: 15908426
DOI: 10.1074/jbc.M503500200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15908426-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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