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Article

Reduced FOXP3(+) regulatory T cells in patients with primary sclerosing cholangitis are associated with IL2RA gene polymorphisms.

Journal of hepatology - 1 May 2014

Sebode Marcial, Peiseler Moritz, Franke Björn, Schwinge Dorothee, Schoknecht Tanja, Wortmann Frederike, Quaas Alexander, Petersen Britt-Sabina, Ellinghaus Eva, Baron Udo, Olek Sven, Wiegard Christiane, Weiler-Normann Christina, Lohse Ansgar W, Herkel Johannes, Schramm Christoph

Abstract excerpt

BACKGROUND & AIMS: Recently, genome wide association studies in primary sclerosing cholangitis (PSC) revealed associations with gene polymorphisms that potentially could affect the function of regulatory T cells (Treg). The aim of this study was to investigate Treg in patients with PSC and to associate their numbers with relevant gene polymorphisms. METHODS: Treg frequency in blood was assessed by staining for...

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Source

Identifiers

PMID: 24412607
DOI: 10.1016/j.jhep.2013.12.027

Genes

FOXP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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