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Functional defects in CD4+ CD25high FoxP3+ regulatory cells in ankylosing spondylitis

30 Nov 2016

Abstract excerpt

Forkhead box P3 (FoxP3)-positive regulatory T cells (Tregs) play a pivotal role in the preservation of self-tolerance, and Treg dysfunction has been implicated in many autoimmune diseases. Whether and how Tregs participate in the pathogenesis of ankylosing spondylitis (AS) has not been fully elucidated. Here, we investigated Treg function and found that Tregs in peripheral blood (PB) from patients with active AS...

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PMID: 27901054
DOI: 10.1038/srep37559

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