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Assessment of the potential impact of polymorphisms in the Foxp3 and CTLA-4 genes in immune balance and disease susceptibility of primary Sjögren's syndrome.

Pharmacogenetics and genomics - 1 Jul 2025

Feng Min, Meng Fanxing, Wang Yanlin, Jia Yuhan, Ji Guozhen, Jin Yue, Gao Chong, Luo Jing

Abstract excerpt

BACKGROUND: Regulatory T (Treg) cell depletion-associated immune tolerance deficiency have been shown to play a key role in the pathogenesis of primary Sjögren's syndrome (pSS). Treg cells mainly express the transcriptional regulator Foxp3 and are characterized by constitutively high expression of inhibitory coreceptor CTLA-4 . Herein, the aim of this study was to investigate the potential association of single...

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PMID: 40279157
DOI: 10.1097/FPC.0000000000000567

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SSB

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