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Article

Increased sensitivity of Treg cells from patients with PBC to low dose IL-12 drives their differentiation into IFN-γ secreting cells.

Journal of autoimmunity - 1 Nov 2018

Liaskou Evaggelia, Patel Samita R, Webb Gwilym, Bagkou Dimakou Danai, Akiror Sarah, Krishna Mahesh, Mells George, Jones Dave E, Bowman Simon J, Barone Francesca, Fisher Benjamin A, Hirschfield Gideon M

Abstract excerpt

IL-12 is a pro-inflammatory cytokine that induces the production of interferon-γ (IFNγ) and favours the differentiation of T helper 1 (Th1) cells. In the presence of IL-12 human Treg cells acquire a Th1-like phenotype with reduced suppressive activity in vitro. Primary biliary cholangitis (PBC) is an autoimmune cholestatic liver disease characterised by high Th1 and Th17 infiltrating cells, reduced frequencies of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30119881
DOI: 10.1016/j.jaut.2018.07.020

Genes

STAT4
IFNG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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