Article
Synovial and peripheral blood CD4+FoxP3+ T cells in spondyloarthritis.
The Journal of rheumatology - 1 Nov 2011
Appel Heiner, Wu Peihua, Scheer Rebecca, Kedor Claudia, Sawitzki Birgit, Thiel Andreas, Radbruch Andreas, Sieper Joachim, Syrbe Uta
Abstract excerpt
OBJECTIVE: Regulatory T cells are characterized by expression of the transcription factor FoxP3 and are thought to be involved in the pathogenesis of autoimmune diseases. We determined the frequency and phenotypic characteristics of CD4+FoxP3+ T cells in the blood and synovial fluid (SF) of patients with inflammatory joint diseases. METHODS: SF from 10 patients with ankylosing spondylitis (AS), 20 patients with...
Topics
- Adult
- Aged
- Arthritis, Psoriatic
- Arthritis, Reactive
- Arthritis, Rheumatoid
- Blood Cells
- CD4 Antigens
- Case-Control Studies
- Cell Count
- Cytokines
- Forkhead Transcription Factors
- Humans
- Interleukin-2 Receptor alpha Subunit