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Article

BAG1 modulates huntingtin toxicity, aggregation, degradation, and subcellular distribution.

Journal of neurochemistry - 1 Nov 2009

Sroka Kamila, Voigt Aaron, Deeg Sebastian, Reed John C, Schulz Jörg B, Bähr Mathias, Kermer Pawel

Abstract excerpt

Bcl-2-associated athanogene-1 (BAG1) is a multifunctional protein delivering chaperone-recognized unfolded substrates to the proteasome for degradation. It has been shown to be essential for proper CNS development in vivo, playing a crucial role in neuronal survival and differentiation. With regard to Huntington's disease, a sequestration of BAG1 into inclusion bodies and a neuroprotective effect in double...

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Source

Identifiers

PMID: 19712056
DOI: 10.1111/j.1471-4159.2009.06363.x

Genes

BAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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