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Article

Oxidative stimuli affect polyglutamine aggregation and cell death in human mutant ataxin-1-expressing cells.

Neuroscience letters - 4 Sept 2003

Kim Sung-Jo, Kim Tae-soo, Hong Sunghoi, Rhim Hyangshuk, Kim Ick Young, Kang Seongman

Abstract excerpt

Spinocerebellar ataxia 1 (SCA1), one of the inherited polyglutamine neurodegenerative diseases, is associated with intracellular aggregates. However, the process of aggregate formation and the factors that influence aggregation remain unclear. Here, we show that oxidative stimuli and alteration of the cellular redox state significantly affect aggregation and cell death in cells expressing mutant ataxin-1, the SCA...

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Identifiers

PMID: 12893416
DOI: 10.1016/s0304-3940(03)00657-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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