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Article

Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models.

The Journal of biological chemistry - 14 Oct 2005

Fujimoto Mitsuaki, Takaki Eiichi, Hayashi Tetsuya, Kitaura Yasushi, Tanaka Yasunori, Inouye Sachiye, Nakai Akira

Abstract excerpt

Polyglutamine diseases are inherited neurodegenerative diseases characterized by misfolding and aggregation of proteins possessing expanded polyglutamine repeats. As overexpression of some heat shock protein (Hsp) suppresses polyglutamine aggregates and cell death, it is assumed that combined overexpression of Hsps will suppress that more effectively. Here, we examined the impact of active forms of heat shock...

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Source

Identifiers

PMID: 16051598
DOI: 10.1074/jbc.M506288200

Genes

HSF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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