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Article

Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice.

The American journal of pathology - 1 Feb 2005

Ikeda Masaki, Shoji Mikio, Kawarai Toshitaka, Kawarabayashi Takeshi, Matsubara Etsuro, Murakami Tetsuro, Sasaki Atsushi, Tomidokoro Yasushi, Ikarashi Yasushi, Kuribara Hisashi, Ishiguro Koichi, Hasegawa Masato, Yen Shu-Hui, Chishti M Azhar, Harigaya Yasuo, Abe Koji, Okamoto Koichi, St George-Hyslop Peter, Westaway David

Abstract excerpt

Missense mutations of the tau gene cause autosomal dominant frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), an illness characterized by progressive personality changes, dementia, and parkinsonism. There is prominent frontotemporal lobe atrophy of the brain accompanied by abundant tau accumulation with neurofibrillary tangles and neuronal cell loss. Using a hamster prion protein gene...

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Identifiers

PMID: 15681835
DOI: 10.1016/S0002-9440(10)62274-2
PMCID: PMC1602315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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