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Article

The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans.

Neurotoxicology - 1 Mar 2014

Estevez Annette O, Morgan Kathleen L, Szewczyk Nathaniel J, Gems David, Estevez Miguel

Abstract excerpt

Exposures to high levels of environmental selenium have been associated with motor neuron disease in both animals and humans and high levels of selenite have been identified in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis (ALS). We have shown previously that exposures to high levels of sodium selenite in the environment of Caenorhabditis elegans adult animals can induce neurodegeneration...

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Identifiers

PMID: 24406377
DOI: 10.1016/j.neuro.2013.12.012
PMCID: PMC3979119

Genes

PTEN
PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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