Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selenium induces cholinergic motor neuron degeneration in Caenorhabditis elegans.

Neurotoxicology - 1 Oct 2012

Estevez Annette O, Mueller Catherine L, Morgan Kathleen L, Szewczyk Nathaniel J, Teece Luke, Miranda-Vizuete Antonio, Estevez Miguel

Abstract excerpt

Selenium is an essential micronutrient required for cellular antioxidant systems, yet at higher doses it induces oxidative stress. Additionally, in vertebrates environmental exposures to toxic levels of selenium can cause paralysis and death. Here we show that selenium-induced oxidative stress leads to decreased cholinergic signaling and degeneration of cholinergic neurons required for movement and egg-laying in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adjuvants, Immunologic
Share to Cholinergic Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Galactosides

Share to Movement

Share to Nerve Degeneration

Share to Paralysis

Share to Receptors, Cholinergic

Share to Selenium

Source

Open in PubMed Open full text

Identifiers

PMID: 22560997
DOI: 10.1016/j.neuro.2012.04.019
PMCID: PMC3445719

Genes

GLRX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selenium induces cholinergic motor neuron degeneration in Caenorhabditis elegans.PMID 22560997Read ↗

Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signalingSemantic proximity Read ↗

The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans.Semantic proximity Read ↗

Caenorhabditis elegans Models CountSemantic proximity Read ↗

A <i>C. elegans</i> genome-wide RNAi screen for altered levamisole sensitivity identifies genes required for muscle functionSemantic proximity Read ↗

Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in <i>C. elegans</i>Semantic proximity Read ↗

An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans.Semantic proximity Read ↗

Amyotrophic Lateral Sclerosis Mechanism: Insights from the Caenorhabditis elegans ModelsSemantic proximity Read ↗

Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells.Semantic proximity Read ↗

Modulating the endoplasmic reticulum stress response attenuates neurodegeneration in a Caenorhabditiselegans model of spinal muscular atrophy.Semantic proximity Read ↗

Neuro-intestinal acetylcholine signalling regulates the mitochondrial stress response in Caenorhabditis elegansSemantic proximity Read ↗

Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseasesSemantic proximity Read ↗

Caenorhabditis elegans: a model to investigate oxidative stress and metal dyshomeostasis in Parkinson's diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.