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Article

Age- and manganese-dependent modulation of dopaminergic phenotypes in a C. elegans DJ-1 genetic model of Parkinson's disease.

Metallomics : integrated biometal science - 1 Feb 2015

Chen Pan, DeWitt Margaret R, Bornhorst Julia, Soares Felix A, Mukhopadhyay Somshuvra, Bowman Aaron B, Aschner Michael

Abstract excerpt

Parkinson's disease (PD) is the second most common neurodegenerative disease, yet its etiology and pathogenesis are poorly understood. PD is characterized by selective dopaminergic (DAergic) degeneration and progressive hypokinetic motor impairment. Mutations in dj-1 cause autosomal recessive early-onset PD. DJ-1 is thought to protect DAergic neurons via an antioxidant mechanism, but the precise basis of this...

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PMID: 25531510
DOI: 10.1039/c4mt00292j
PMCID: PMC4479152

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Source receipt: pubmed, retrieved 7 Sept 2026.

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