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Article

Evaluation of INK4A promoter methylation using pyrosequencing and circulating cell-free DNA from patients with hepatocellular carcinoma.

Clinical chemistry and laboratory medicine - 1 Jun 2014

Huang Gengming, Krocker Joseph D, Kirk Jason L, Merwat Shehzad N, Ju Hyunsu, Soloway Roger D, Wieck Lucas R, Li Albert, Okorodudu Anthony O, Petersen John R, Abdulla Nihal E, Duchini Andrea, Cicalese Luca, Rastellini Cristiana, Hu Peter C, Dong Jianli

Abstract excerpt

BACKGROUND: Hyper-methylation of CpG dinucleotides in the promoter region of inhibitor of cyclin-dependent kinase 4A (INK4A) has been reported in 60%-80% of hepatocellular carcinoma (HCC). As INK4A promoter hypermethylation event occurs early in HCC progression, the quantification of INK4A promoter methylation in blood sample may represent a useful biomarker for non-invasive diagnosis and prediction of response...

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Share to Carcinoma, Hepatocellular
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to DNA Methylation

Share to Liver Neoplasms

Share to Promoter Regions, Genetic

Source

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Identifiers

PMID: 24406287
DOI: 10.1515/cclm-2013-0885
PMCID: PMC4532549

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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