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Article

The Role of Pyrosequencing in Head and Neck Cancer Epigenetics

1 Mar 2008

Abstract excerpt

OBJECTIVE: To evaluate promoter methylation quantitation using recently described pyrosequencing techniques by correlation with messenger RNA (mRNA) expression. DESIGN: DNA was extracted from tissue samples and was subjected to bisulphite conversion. Quantitative methylation data for multiple CpG sites in each of 9 gene promoters were obtained for tumors using pyrosequencing. RNA was extracted and converted to...

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PMID: 18347248
DOI: 10.1001/archoto.2007.50

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