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Article

Plasma cell-free DNA methylation: a liquid biomarker of hepatic fibrosis

20 Jan 2018

Abstract excerpt

We recently reported dynamic epigenetic markers of fibrosis detectable in patients’ plasma that may have utility in non-invasive diagnosis and staging of fibrosis in patients with chronic liver disease.1 Specifically, we uncovered DNA methylation markers at the human PPARγ promoter detectable in circulating cell-free DNA (ccfDNA) that display differential methylation densities. Remarkably, PPARγ hypermethylation...

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PMID: 29353249
DOI: 10.1136/gutjnl-2017-315668

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