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Targeted Deep DNA Methylation Analysis of Circulating Cell-free DNA in Plasma Using Massively Parallel Semiconductor Sequencing

1 Jun 2015

Abstract excerpt

AIM: To set up a targeted methylation analysis using semiconductor sequencing and evaluate the potential for studying methylation in circulating cell-free DNA (cfDNA). MATERIALS & METHODS: Methylation of VIM, FBLN1, LTBP2, HINT2, h19 and IGF2 was analyzed in plasma cfDNA and white blood cell DNA obtained from eight hepatocellular carcinoma patients and eight controls using Ion Torrent™ PGM sequencer. RESULTS: h19...

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PMID: 26077425
DOI: 10.2217/epi.14.94

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