Article
A pyrosequencing assay for the quantitative methylation analysis of the PCDHB gene cluster, the major factor in neuroblastoma methylator phenotype.
Laboratory investigation; a journal of technical methods and pathology - 1 Mar 2012
Banelli Barbara, Brigati Claudio, Di Vinci Angela, Casciano Ida, Forlani Alessandra, Borzì Luana, Allemanni Giorgio, Romani Massimo
Abstract excerpt
Epigenetic alterations are hallmarks of cancer and powerful biomarkers, whose clinical utilization is made difficult by the absence of standardization and of common methods of data interpretation. The coordinate methylation of many loci in cancer is defined as 'CpG island methylator phenotype' (CIMP) and identifies clinically distinct groups of patients. In neuroblastoma (NB), CIMP is defined by a methylation...
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