Article
Loci-specific differences in blood DNA methylation in HBV-negative populations at risk for hepatocellular carcinoma development.
Epigenetics - 1 Jan 2018
Lubecka Katarzyna, Flower Kirsty, Beetch Megan, Qiu Jay, Kurzava Lucinda, Buvala Hannah, Ruhayel Adam, Gawrieh Samer, Liangpunsakul Suthat, Gonzalez Tracy, McCabe George, Chalasani Naga, Flanagan James M, Stefanska Barbara
Abstract excerpt
Late onset of clinical symptoms in hepatocellular carcinoma (HCC) results in late diagnosis and poor disease outcome. Approximately 85% of individuals with HCC have underlying liver cirrhosis. However, not all cirrhotic patients develop cancer. Reliable tools that would distinguish cirrhotic patients who will develop cancer from those who will not are urgently needed. We used the Illumina HumanMethylation450...
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