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A circulating cell-free DNA methylation signature for the detection of hepatocellular carcinoma

6 Oct 2023

Abstract excerpt

To address the shortcomings of current hepatocellular carcinoma (HCC) surveillance tests, we set out to find HCC-specific methylation markers and develop a highly sensitive polymerase chain reaction (PCR)-based method to detect them in circulating cell-free DNA (cfDNA). The analysis of large methylome data revealed that Ring Finger Protein 135 (RNF135) and Lactate Dehydrogenase B (LDHB) are universally applicable...

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PMID: 37803338
DOI: 10.1186/s12943-023-01872-1

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